Let LDN Lift You Up!

All the rage is all about Low-Dose Naltrexone (LDN).  Why?  Because auto-immune disease and depression anxiety in 2021 just happens to be growing at a rapid rate due to a variety of reasons.  LDN to the rescue!  The benefits of this little white capsule are so profound, it could eventually be as essential as H2O. Not that we are bias or anything.

The Benefits of LDN Include:

• Reduces Pain and Inflammation
• Fights Cancer causing free radicals.
• Improved Mood
• Weight Loss
• Better Sleep

This list is just the beginning.  LDN can aide in the fight against a long list of diseases like Hashimoto’s, for instance.  This is because of the way LDN attaches itself to opioid receptors in our brain, as a result, endorphins are ignited.  Endorphins are the feel-good hormones that we experience when we do the things that bring us joy.  For example, exercising, eating, intercourse, and laughter are all major contributors to the release of endorphins.

LDN and Disease

The long list of auto-immune diseases LDN can help aide or eliminate are:

• Certain types of cancers, such as breast cancer
• Fibromyalgia
• Ulcerative colitis
• Crohn’s Disease
• Cardiomyopathy
• Multiple sclerosis
• Rheumatoid arthritis
• Chronic pain
• Hashimoto’s thyroiditis
• Kawasaki’s disease
• Epstein Barr virus
• Pernicious anemia
• Lupus
• Scleroderma

We believe this is just the beginning of what LDN can do.  As time marches on, we believe the findings will be groundbreaking in healing our world of so many painstaking diseases.

We All Have A Past, So Does Naltrexone

Naltrexone has been performing at a very high success rate in the field of addiction since 1962, as the years progressed, so did the discoveries of what Naltrexone given in lower doses can accomplish.  The timeline below is from the LDN Science Laboratories:

1962

Naltrexone Discovered

Naltrexone first synthesized by Endo Laboratories in Long Island, NY

1980

“Low Dose” Naltrexone (LDN) Discovered

LDN effects against cancer discovered by Drs. Ian S. Zagon and Patricia J. McLaughlin at Penn State University

1983

“Science” Publishes First LDN Papers

Two papers published in “Science” showing LDN effect on cancer and cell-growth

1984

US FDA Approves Naltrexone

Naltrexone (50mg dose) approved for treating heroin and opiate dependence

1985

LDN First Used for MS

Dr. Bernard Bihari first uses LDN in an MS patient

1987

LDN Tried in AIDS Patients

Dr. Bernard Bihari tests LDN in AIDS patients at State University of New York

2002

2,000 MS Patients Using LDN

2,000 MS patients taking LDN prescribed by Dr. Bihari and other physicians

2003

LDN Clinical Trial for Crohn’s Disease

LDNscience^® founder Moshe Rogosnitzky initiates first clinical trial of LDN for Crohn’s disease at Hershey Medical Center, Penn State University

2004

“LDN Research Trust” Established

First global LDN charity established in United Kingdom

2006

Use in Pancreatic Cancer Published

Dr. Burt Berkson publishes first case report of LDN for pancreatic cancer

2007

First LDN Clinical Trial Results Published

First-ever clinical trial of LDN (in Crohn’s disease) published by Drs. Smith, Zagon, McLaughlin and Moshe Rogosnitzky

2007

LDN for MS Trial Results Published

First clinical trial in MS published by Dr. Maira Gironi of San Raffaele Scientific Institute, Italy

2009

LDNscience^® Launched

MedInsight Research Institute launches LDNscience.org – with first LDN worldwide physician directory.

LDN for Fibromyalgia Trial Results Published.

Drs. Sean Mackey and Jarred Younger of Stanford University publish first LDN trial in fibromyalgia.

LDN for Duodenal Crohn’s Disease was established.

Duodenal Crohn’s case report published by Cleveland Clinic.

2010

US FDA Grants Orphan Designation for LDN

FDA grants orphan designation for LDN in pediatric Crohn’s disease

Second MS Trial Published

UCSF publishes results of second MS trial

2011

LDN for HIV Trial Published

LDN in HIV+ adults in Mali trial results published

2013

Second Fibromyalgia Study Published

Stanford researchers publish second fibromyalgia study

Pediatric Crohn’s Disease Trial Published

Penn State researchers publish first LDN trial in pediatric Crohn’s disease

LDN for Pediatric Liver Cancer

Researchers from MedInsight and Texas Children’s Hospital publish first case of LDN use in pediatric hepatoblastoma (liver cancer)

2014

12 New Publications About LDN

Researchers from 6 countries publish 12 new reports/studies about LDN in multiple disorders

2015

New LDN Results for Pain and Neuropathy

Seven new reports/studies published about LDN including studies in various pain syndromes

2016

>300,000 Patients Using LDN

Data from naltrexone manufacturers show >300,000 patients worldwide now using LDN

2016

LDNscience^® New Site Launched

MedInsight launches revamped and enhanced LDNscience^® site

2017

LDN Mechanism of Action Clarified

LDN shown to benefit Multiple Sclerosis (MS) via restoring OGF (methionine enkephalin) levels

A First for LDN in Ophthalmology

Tufts University experts recommend LDN for Neuropathic Corneal Pain (NCP)

2018

Global LDN Supplier Directory Launched

LDNscience^® creates free online directory of >200 LDN suppliers worldwide

LDN Studied at >60 Academic Institutions

More than 60 leading academic institutions from across the globe are involved in LDN research

First Clinical Trial in Animals

LDN shown to increase the benefits of chemotherapy in treating breast cancer in dogs

2019

Ten New Conditions Studied with LDN

Ten new LDN indications were researched including: chronic fatigue syndrome, osteoporosis, rheumatoid arthritis, Sjögren’s syndrome, and Ehlers Danlos syndrome

Record-Breaking Year in LDN Studies

2019 saw 35 newly published LDN articles by more than 100 authors- more than any previous year

2020

First Clinical Trial of LDN to Treat COVID-19

William Beaumont Hospital in Michigan, USA launches the first clinical trial of LDN to treat COVID-19

New LDN indications researched

Trigeminal neuralgia; hyperinsulinemia, COVID-19, colorectal cancer; erythromelalgia, vulvar HHD

LDN in 2021

Recent studies have proven substantial benefits in the use of low-dose naltrexone for the treatment of chronic pain.  Diseases such as fibromyalgia, IBS, multiple sclerosis, depression, and anxiety all show a significant reduction in symptoms when treated with LDN.  This is a result of the releasing of inflammatory chemicals in the central nervous system.   The discoveries as to all this little miracle pill can do will only increase as studies continue.

LDN and Diminishing Depression

Due to the insane stresses revolving around our world today, depression and anxiety are at an all-time high.  These stressors are not only mental and emotional, but they are also environmental and physical.  Covid-19 brought about a multitude of new ways to feel stress as millions of people were fired or furloughed from their jobs.  It could all be coincidence, but we are thankful for the years of research surrounding LDN and its’ benefits for a world gone a little (or a lot) crazy.

Science and All That Jazz

Low Dose Naltrexone is prescribed at doses between 0.5-4.5 mg, which at that low dose briefly blocks the opioid receptors for a few hours. Subsequently a rebound effect occurs, with increased production of endorphins, resulting in an enhanced feeling of well-being, as well as a reduction in pain and inflammation. (Psychology Today, 2019)

The only side-effects that were found in any patients using LDN for depression were vivid dreams due to a deeper sleep.  These subsided after a few weeks and only returned if the dosage was increased.  Other side effects were headaches and GI issues, both due to possible dehydration from their bodies working appropriately for the first time in years.  When this happens, our bodies begin to use and need the water as intended instead of feeling swollen from GI blockages etc.

Beyond Our Products

Although we committed an entire blog to our new favorite wonder drug, we also see benefits in minor or major life changes to help with certain chronic pain disorders and depression.  To reach a true sense of well-being daily in our world today, there must be focus and determination.  Leave plenty of room for self-care, reflection, prayer, yoga, sitting in a park, playing with a puppy, volunteering, travel etc.  All of these things along with a list of thousands of others can help us lead a depressed-free life.  Depression and anxiety can often lead to chronic pain or vice-versa, so as much as we love LDN, we love self-care even more… and puppies, we love the most!

Tip of The Day:

Herbs have it!  Planting an herb garden can bring more peace, joy, flavor and financial benefits than you probably know.    Gardening has been said to lessen stress by more than 50% due to its effects on our brain balance, much like doing a puzzle.  It allows our minds to decompress without completely checking out because we are still using our minds, just not in a stressful way. More benefits include the flavor you’ll be able to add to your everyday meals without breaking the bank at the store.  Some of the most popular herbs for planting indoors are rosemary, basil, thyme, chives, mint, and oregano.  If you are new to the herb world, maybe start with 3 and take it from there.  You’ll be feeling less stressed in no time, not to mention gaining a new skill in your repertoire.  Cheers to spicing things up while you’re winding down!