TriMix is indicated in the treatment of erectile dysfunction in males. TriMix contains three drugs from complimentary classes designed to act synergistically, mixed into a sterile injection. TriMix is administered as a penile self-injection, typically considered to be the most powerful class of anti-erectile dysfunction agents. While the components of TriMix (Papaverine, Phentolamine, Prostaglandin E1) are, on their own, indicated for a vast number of different conditions, the practice of bringing them together in concert to treat erectile dysfunction has become commonplace in sexual medicine and is now considered to be the go-to treatment if conventional PDE5 inhibitors are contraindicated or non responsive.

Trimix is most useful for men who cannot take oral medication or for those who have failed on PDE5 inhibitors such as Viagra or Cialis. Penile injections, such as Trimix, have
a faster onset of action than most oral medications. An erection is achieved in less than 5 minutes from administration

Phenylephrine is used as an antidote when needed and is recommended to treat priapism if needed.

5 mL vial of TriMix plus Antidote, supply varies depending on dose. 1^st time use must start with TriMix with Antidote, future refills may purchase without Antidote.